Currently, the Social and Solidarity Economy (SSE) is a phenomenon that has gained increasing economic, social and political visibility. However, these experiences are marked by challenges associated to the modus operandi that makes its continuity or advances impossible or difficult, in many cases. Such challenges exist due to several economic aspects, such as administrative and management, political, social, educational, scientific, technological, environmental, legal and also those related to accounting. Besides, there are many restrictions in what concerns the need to advance in matters such as the regulatory framework of public policies of SSE, of its institutionalization and financing. These restrictions put obstacles to the advancement of SSE. An “entrepreneurial ecosystem” is a community within a region of interdependent actors with diverse roles that interact, determining the performance of the ecosystem and eventually the entire economy of a region. As a result of the performance of the ecosystem, it is expected that, in addition to the results obtained by companies and organizations components (in terms of performance and learning), the lightweight interaction generating new businesses. The SSE cannot be restricted to the development of simple and disjointed activities of local productivity. For this it is necessary to think the articulation of the SSE with other social enterprises and public and private institutions in local production. In this sense, this article intends to discuss the newest developments in the construction of the entrepreneurial ecosystem for SSE and the role of the International Labour Organization (ILO).